A collaborative paper on small non-coding RNAs in the regenerating Planerian worm

Vidyanand Sasidharan and co-workers from Dasaradhi Palakodeti's lab at InSTEM, have been working on a project describing the non-coding RNA profile of the regenerating Planerian worm. The results of their work have appeared as an article in the journal RNA

The following is the abstract of this paper:

In recent years, the planarian Schmidtea mediterranea has emerged as a tractable model system to study stem cell biology and regeneration. MicroRNAs are small RNA species that control gene expression by modulating translational repression and mRNA stability and have been implicated in the regulation of various cellular processes. Though recent studies have identified several miRNAs in S. mediterranea, their expression in neoblast subpopulations and during regeneration has not been examined. Here, we identify several miRNAs whose expression is enriched in different neoblast subpopulations and in regenerating tissue at different time points in S. mediterranea. Some of these miRNAs were enriched within 3 h post-amputation and may, therefore, play a role in wound healing and/or neoblast migration. Our results also revealed miRNAs, such as sme-miR-2d-3p and the sme-miR-124 family, whose expression is enriched in the cephalic ganglia, are also expressed in the brain primordium during CNS regeneration. These results provide new insight into the potential biological functions of miRNAs in neoblasts and regeneration in planarians.                   


We are funded by NCBS (DAE), DST, CSIR, DBT. and UGC