Lab News

Paper on genome-wide structural variations impacting xenogene silencing

In a paper, just published in Nucleic Acids Research, we use laboratory evolution and genome sequencing to show that a large duplication of ~40% of the chromosome, centred around the origin or replication and comprising many highly expressed genes, can compensate for the global gene expression imbalance caused by a perturbation of gene silencing operating on horizont

Paper on the evolution of antibiotic resistance in the laboratory

In a paper, just published in DNA Research, we use laboratory evolution and genome sequencing to show that the benign laboratory workhorse Escherichia coli, when exposed to sub-lethal concentration of an aminoglycoside antibiotic, rapidly develops low-cost mutations that confer resistance to antibiotic.

A couple of research grants this year!

Over the last few months, our lab has received two research grants from bodies of the Government of India. The first, from the Department of Biotechnology, will allow us to investigate stationary phase physiology of Escherichia coli on a genomic sclae. The seond, from the Department of Science and Technology, is for an investigation of the function of the xenogene silencing system - H-NS - in E. coli.

A collaborative paper on small non-coding RNAs in the regenerating Planerian worm

Vidyanand Sasidharan and co-workers from Dasaradhi Palakodeti's lab at InSTEM, have been working on a project describing the non-coding RNA profile of the regenerating Planerian worm. The results of their work have appeared as an article in the journal RNA.

The following is the abstract of this paper:

Bacterial Expressions, an international conference on bacterial gene expression and evolution (Oct 22-25, 2013)

Watch this space for a summary of the outcomes of what was a successful conference!

Keeping foreign DNA silent - the role of DNA sequences and molecular backups

In a paper, just published in Molecular Biosystems, we report that both DNA sequences and the need for back-up mechanisms for gene silencing in Escherichia coli might be selected for targeting highly transcribable genes.

Beefing up the manipulation of the immune system: a novel prophage in Indian Staphylococcus aureus

In a paper, just published in PLoS ONE, we report the presence of a novel prophage (viral DNA that is integrated in the host bacterial chromosome) in the genome of S. aureus from India (sequence type 772). This prophage carries two toxins, both of which are capable of manipulating the host immune system.

Book on Bacterial Genomics Released by Cambridge University Press

Cambridge University Press has released a new book on Bacterial Genomics, written by Aswin.

On CUP, India website

On CUP, worldwide website

You are here

Lab News